Tag nrho lub tshuab ziab khaub ncaws, lyophilizer thiab khov tshuab ziab khaub ncaws ua tiav cov khoom ua kom lub cev qhuav dej los ntawm kev sib koom ua ke - tshuab ziab khaub ncaws thiab lyophilization, thiab tag nrho cov txheej txheem tau muab faib ua peb theem tseem ceeb: ua ntej- khov, thawj ziab (sublimation), thiab theem nrab ziab (desorption), uas muaj feem xyuam rau ob qho tib si} freezetoplyophilizer.
Thawj theem yog ua ntej - khov. Lub tshuab nqus tsev vacuum khov sai sai txo qhov kub ntawm sab hauv kom qis dua peb npaug ntawm dej, khov tag nrho cov dej noo hauv cov khoom rau hauv cov dej khov. Cov kauj ruam no yog lub hauv paus ntawm lyophilization, uas tuaj yeem tiv thaiv cov khoom los ntawm melting thiab kev puas tsuaj thaum lub sij hawm tom qab khov- ziab, thiab tiv thaiv cov khoom xyaw ntawm cov cua sov- cov ntaub ntawv rhiab heev.
Qhov thib ob theem yog thawj ziab, tseem hu ua sublimation ziab. Lub tshuab ziab khaub ncaws kom qhuav pib lub tshuab nqus tsev kom tsim tau qhov tsawg- lub tshuab nqus tsev nyob hauv lub chamber. Nyob rau hauv qhov tshwj xeeb tsis tshua muaj kub thiab lub tshuab nqus tsev, cov dej khov hauv cov khoom ncaj qha sublimes rau hauv dej vapor yam tsis muaj melting rau hauv dej, uas tshem tawm ntau tshaj 80% ntawm cov khoom ya raws.
Qhov thib peb theem yog theem nrab ziab, uas yog desorption ziab. Lub tshuab ziab khaub ncaws muaj thiab lub rooj ntev zaum- lub tshuab ziab khaub ncaws saum toj kawg nkaus yuav tsim kom muaj qhov kub thiab txias thiab kho lub tshuab nqus tsev kom tshem tawm cov dej khi rau hauv cov khoom. Cov kauj ruam no ntxiv txo cov dej noo ntawm cov khoom tiav thiab ua kom lub sij hawm ntev - cia ruaj khov ntawm khov- cov khoom qhuav.
Kev sib koom ua ke ntawm peb theem txiav txim siab qhov kawg ntawm cov khoom lyophilization. High -Lub tshuab ziab khaub ncaws zoo thiab cov khoom siv lyophilizer tuaj yeem kho qhov kub thiab txias, lub tshuab nqus tsev kawm ntawv thiab lub sijhawm ntsuas raws li cov ntaub ntawv sib txawv, zam cov khoom shrinkage, oxidation thiab active ingredient poob los ntawm kev khov tsis raug - ziab.
Txawm hais tias nws yog qhov chaw sim me me -batch ua los yog kev lag luam ntau lawm, cov txheej txheem khov kho- ziab thiab lyophilization txheej txheem tswj yog tus yuam sij rau kev ua tau zoo - khov zoo- cov khoom qhuav, uas tseem yog qhov tseem ceeb ntawm kev ua haujlwm zoo ntawm cov tshuab nqus tsev khov thiab khov tshuab ziab khaub ncaws.
